SMALL-AREA VARIATION OF CARDIOVASCULAR DISEASES AND SELECT RISK FACTORS AND THEIR ASSOCIATION TO HOUSEHOLD AND AREA POVERTY IN SOUTH AFRICA: CAPTURING EMERGING TRENDS IN SOUTH AFRICA TO BETTER TARGET LOCAL LEVEL INTERVENTIONS.

Small-area variation of cardiovascular diseases and select risk factors and their association to household and area poverty in South Africa: Capturing emerging trends in South Africa to better target local level interventions.

BackgroundOf the total 56 million deaths worldwide during 2012, 38 million (68%) were due to noncommunicable diseases (NCDs), particularly cardiovascular diseases (17.5 million deaths) cancers (8.2 million) which represents46.2% and 21.7% of NCD deaths, respectively).Nearly 80 percent of the global CVD deaths occur in low- and middle-income countri

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Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

Summary: Neuroferritinopathy (NF) is a movement disorder caused by alterations in the L-ferritin gene that generate cytosolic free iron.NF is a unique pathophysiological model for determining the direct consequences of cell iron dysregulation.We established lines of induced pluripotent stem cells from Four Wheel Rollators fibroblasts from two NF pa

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